Shou Aikawa as Kouichi Takasugi (高杉浩一)
Takasugi is a loan shark from Nagoya who’s pursuing former baseball star Tatsuo Shinada, one of the game’s five main characters..
Shunsuke Daitou as Shigeki Baba (馬場茂樹)
Baba is a prisoner in Hokkaido whose life changes greatly when he meets Taiga Saejima.
Nana Katase as Mayumi (まゆみ)
Mayumi works at a club in Fukuoka. She plays a major part in the story of Kiryu and the other main characters and will also appear in the other four cities.
Satoshi Tokushige as Daigo Dojima (堂島大吾)
Daigo first appeared in the Yakuza series in Yakuza 2. Tokushige says that his line count has gone up many times for Yakuza 5.
Mitsuru Fukikoshi as Naoki Katsuya (勝矢直樹)
Katsuya is the head of a talent production company with ties to organized crime.
Eiji Okuda as a Detective in Osaka
Okuda’s character is surrounded by mystery. The character is apparently pursuing the main characters.